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Blood Cells Mol Dis. 2005 Jul-Aug;35(1):21-6.

Exosome release by reticulocytes--an integral part of the red blood cell differentiation system.

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  • 1UMR CNRS 5539, UniversitĂ© Montpellier II-cc107, 34095 Montpellier, France.


Reticulocyte maturation into erythrocytes is the final step of erythropoiesis that occurs in the blood circulation. This terminal differentiation period corresponds to a cellular remodeling phase following expulsion of the nucleus into the bone marrow. Among other events, this remodeling leads to the disappearance of intracellular organelles and acquisition of the typical cellular biconcave form. Here, we propose that exosome biogenesis and secretion, which contributes to net loss of the cell surface membrane via selective vesicular membrane secretion, is also closely interconnected with upstream (nucleus expulsion), accompanying (mitoptosis) and downstream (vesicle clearance) events.

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