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Immunohematology. 1990;6(1):9-11.

An example of anti-JMH with characteristics of a clinically significant antibody.

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American Red Cross Blood Services, Great Lakes Region, 1800 East Grand Avenue, P.O. Box 30101, Lansing, MI 48909, USA.


The authors studied an example of red cell anti-JMH (John Milton Hagen) that exhibited several characteristics of a possible clinically significant antibody able to cause red cell destruction in vivo. Strong serological reactivity, a positive monocyte monolayer assay, and immunoglobulin subclass determination as IgG3 all indicate possible ability to destroy red cells. A51Cr-labeled red cell survival study was not done as the patient did not require red cell transfusions but may be recommended for this patient if transfusions become necessary.


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