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Aliment Pharmacol Ther. 2005 Jun;21 Suppl 2:37-41.

Effects of famotidine, mosapride and tandospirone for treatment of functional dyspepsia.

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Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo-shi, Shimane, Japan.



An effective therapeutic strategy for functional dyspepsia (FD) has not been well-established.


We investigated and compared the therapeutic effects of famotidine, mosapride and tandospirone for the control of dyspeptic symptoms.


Fully examined FD patients of outpatient clinics at seven different medical centres were enrolled in the study. They were randomly assigned to three groups based on the type of drug administered: famotidine, mosapride and tandospirone. The effects of treatment over 4 weeks were assessed by visual analogue scales.


All of the drugs showed beneficial effects, although famotidine was the most effective for symptom relief, which was significantly greater than tandospirone, while the effect of mosapride was similar to that of famotidine. No subtype of FD showed a better response to a particular type of drug.


For the treatment of FD, famotidine demonstrated the best therapeutic effect, followed by mosapride, while that of tandospirone was significantly lower.

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