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Nano Lett. 2005 Jun;5(6):1023-7.

Novel integrated electrochemical nano-biochip for toxicity detection in water.

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Department of Electrical Engineering--Physical Electronics and TAU Research Institute for Nano Science and Nano-technologies, Tel-Aviv University.


An electrochemical nano-biochip for water toxicity detection is presented. We describe chip design, fabrication, and performance. Bacteria, which have been genetically engineered to respond to environmental stress, act as a sensor element and trigger a sequence of processes, which leads to generation of electrical current. This novel, portable and miniature device provides rapid and sensitive real-time electrochemical detection of acute toxicity in water. A clear signal is produced within less than 10 min of exposure to various concentrations of toxicants, or to stress conditions, with a direct correlation between the toxicant concentration and the induced current.

[Indexed for MEDLINE]

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