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Epilepsy Res. 2005 Jun;65(1-2):117-20.

Ophthalmologic and neurologic findings in two children exposed to vigabatrin in utero.

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Department of Ophthalmology, Kuopio University Hospital, P.O. Box 1777, FIN-70211 Kupio, Finland.


Vigabatrin (VGB) is an important treatment option for infantile spasms. Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug. The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been exposed to VGB in utero is limited. We explored ophthalmic and neurologic findings in two children who have been exposed prenatally to VGB.

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