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Chemistry. 2005 Sep 19;11(19):5523-30.

Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance.

Author information

1
Leibniz Institute for Natural Products Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany.

Abstract

Cervimycins A-D are novel polyketide glycosides with significant activity against multi-drug-resistant staphylococci and vancomycin-resistant enterococci. They are produced by a strain of Streptomyces tendae, isolated from an ancient cave. The structures of the cervimycins were determined by performing extensive NMR and chemical degradation studies. All cervimycins have a common tetracyclic polyketide core that is substituted with unusual di- and tetrasaccharide chains, composed exclusively of trideoxysugars; however, they differ in the acetyl and carbamoyl ring substituent and in the highly unusual terminal methylmalonyl and dimethylmalonyl residues.

PMID:
15940739
DOI:
10.1002/chem.200500320
[Indexed for MEDLINE]

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