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J Clin Oncol. 2005 Aug 10;23(23):5323-33. Epub 2005 Jun 6.

Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer.

Author information

1
Medical Oncology Service, Vall d'Hebron University Hospital, P. Vall d'Hebron 119-129 08035 Barcelona, Spain. jbaselga@vhebron.net

Abstract

PURPOSE:

To evaluate the antitumor activity and pharmacodynamic/biologic effect of gefitinib 500 mg/day monotherapy in patients with previously treated, advanced breast cancer.

METHODS:

In this phase II multicenter trial, the primary objective was assessment of the tumor response rate with gefitinib; secondary objectives included analysis of the pharmacodynamic and biologic profiles in healthy and tumor tissue.

RESULTS:

while phosphorylation of mitogen-activated protein kinase was inhibited in both tissues, gefitinib treatment induced p27 and a decrease in Ki67 in skin but not in tumors. Furthermore, gefitinib did not inhibit the activated form of Akt in the tumors.

CONCLUSION:

This study demonstrates a good correlation between the degree of inhibition of EGFR in skin and in breast tumors. The lack of significant clinical activity of gefitinib in our study population is not due to lack of receptor inhibition in these tumors but rather to lack of EGFR dependence in the tested population.

PMID:
15939921
DOI:
10.1200/JCO.2005.08.326
[Indexed for MEDLINE]
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