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J Exp Med. 2005 Jun 6;201(11):1709-14.

Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man.

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1
Center for Vaccines and Immunity, Columbus Children's Research Institute, Columbus, OH 43205, USA.

Abstract

The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I-restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure.

PMID:
15939787
PMCID:
PMC2213256
DOI:
10.1084/jem.20050808
[Indexed for MEDLINE]
Free PMC Article
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