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Brain Res Dev Brain Res. 2005 Jun 9;157(1):98-102. Epub 2005 Apr 26.

Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain.

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  • 1Adult and Pediatric Epilepsy Program, Department of Pediatrics, PO Box 11-0236/B52 Riad el Solh, American University of Beirut, Beirut 1107-2020, Lebanon.


Ten-day-old rat pups (P10) subjected to acute hypoxia (down to 4% O2) had as adults increased aggression (handling test), memory impairment (water maze test), and decreased CA1 cell counts. Pups subjected to chronic hypoxia (10% O2 from P0 to P21) had increased aggression, hyperactivity (open-field test), and decreased CA1 cell counts. Chronic hypoxia with superimposed acute hypoxia resulted in consequences that were not different from those of chronic hypoxia.

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