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Nat Immunol. 2005 Jul;6(7):698-706. Epub 2005 Jun 5.

CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa.

Author information

1
The CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection.

Comment in

PMID:
15937486
PMCID:
PMC1444945
DOI:
10.1038/ni1212
[Indexed for MEDLINE]
Free PMC Article

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