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Adv Drug Deliv Rev. 2005 Jun 17;57(9):1247-65. Epub 2005 Apr 18.

Particulate delivery systems for biodefense subunit vaccines.

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School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX, UK.


Expanding identification of potentially protective subunit antigens and correlates of protection has provided a basis for the introduction of safer vaccines. Despite encouraging results in animal models, the significant potential of particulate delivery systems in vaccine design has not yet translated into effective vaccines available for use in humans. This review article will focus on the current status of the development of particulate vaccines, mainly liposomes and bio-degradable polymers, against potential agents for biowarfare: plague, anthrax, botulinum, and smallpox; and filoviruses: Marburg and Ebola.

[Indexed for MEDLINE]

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