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Trends Microbiol. 2005 Jul;13(7):328-35.

Naip5/Birc1e and susceptibility to Legionella pneumophila.

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Department of Biochemistry and Center for the Study of Host Resistance, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec, Canada, H3G 1Y6.


Genetic analysis in mice is a powerful approach for the identification of genes and proteins that have a key role at the interface of the host-pathogen interaction. The Lgn1 locus has been found to control the intracellular replication of Legionella pneumophila in murine macrophages. Using functional complementation in transgenic mice, the Naip5/Birc1e gene has been identified as responsible for the Lgn1 effect. The classification of Naip5/Birc1e as a member of the NLR protein family suggests that Naip5/Birc1e acts as an intracellular sensor of L. pneumophila. The nature of the signal transduced by Naip5/Birc1e in response to Legionella products is of great interest but is currently unknown. Here, several possible scenarios are presented.

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