Format

Send to

Choose Destination
Expert Opin Ther Targets. 2005 Apr;9(2):315-28.

Targeting epigenetic regulatory mechanisms in cancer chemoprevention.

Author information

1
CCS Associates, 2005 Landings Dr, Mountain View, CA 94043, USA. jfay@ccsainc.com

Abstract

Dysregulation of the epigenome plays a fundamental role in tumour development. Epigenetic events are a major mechanism for inactivating tumour suppressor and DNA repair genes and occur ubiquitously during the early stages of tumour development. Unlike genes inactivated by mutation, genes silenced epigenetically are intact and potentially responsive to reactivation by small molecules. This review discusses the potential for restoring epigenetic balance as a means to prevent cancer.

PMID:
15934918
DOI:
10.1517/14728222.9.2.315
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center