Format

Send to

Choose Destination
Expert Opin Pharmacother. 2005 May;6(5):835-7.

Sildenafil for the treatment of altitude-induced hypoxaemia.

Author information

1
University of Patras, Medical School, 26500 Rio, Patras, Greece. petperim@upatras.gr

Abstract

Exposure to high altitude causes alveolar hypoxia and induces pulmonary hypertension (PH) with consequent limitation of exercise capacity. To assess the impact of sildenafil on haemodynamic and clinical parameters, and on aerobic performance, 12 young healthy unacclimatised subjects were studied (6 received sildenafil 40 mg t.i.d. and 6 received placebo) at sea level and high altitude. Systolic pulmonary artery pressure increased at high altitude, but normalised with sildenafil. The altitude-induced decrease in maximal O2 consumption was significantly smaller with sildenafil than with placebo. Enhancing pulmonary circulation with sildenafil safely protects against the high altitude-induced PH and improves gas exchange.

PMID:
15934909
DOI:
10.1517/14656566.6.5.835
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center