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Expert Opin Biol Ther. 2005 Apr;5(4):443-9.

Cancer immunotherapy based on the killing of Salmonella typhimurium-infected tumour cells.

Author information

1
University of Minnesota Medical School, 195MMC 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA. saltz002@umn.edu

Abstract

The use of bacteria for anticancer purposes was first attempted over 100 years ago. Recently, several strains of Salmonella have been shown to possess anticancer activity and, interestingly, Salmonella possesses a unique propensity to track to tumour tissue in vivo. This review presents the use of Salmonella for cancer immunotherapy, including the distinguishing characteristics of this organism and preclinical as well as clinical data.

PMID:
15934824
DOI:
10.1517/14712598.5.4.443
[Indexed for MEDLINE]

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