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Zhonghua Nan Ke Xue. 2005 May;11(5):359-61, 364.

[Significance of MMP2 and MMP9 expression in prostate cancer].

[Article in Chinese]

Author information

1
Department of Urology, China PLA General Hospital, Beijing 100853, China. doctorzhxy@163.com

Abstract

OBJECTIVE:

To evaluate the significance of the expression of matrix metalloproteinases (MMPs) in prostate cancer (PCa) and its clinical association.

METHODS:

Fifty one cases of PCa and 10 cases of BPH were studied by immunohistochemical method using monoclonal antibodies to MMP2 and MMP9.

RESULTS:

There was significant correlation between MMP2 or MMP9 and pathological grade, Gleason score and PCa metastasis.

CONCLUSION:

The expression of MMP2 and MMP9 may play an important role in the development and metastasis of PCa.

PMID:
15934460
[Indexed for MEDLINE]

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