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Phytother Res. 2005 Mar;19(3):216-21.

Antioxidant activity of DHC-1, an herbal formulation, in experimentally-induced cardiac and renal damage.

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Pharmacy Department, Faculty of Technology and Engineering, The M.S. University of Baroda, Baroda -390 001, Gujarat, India.


DHC-1, an herbal formulation derived from the popular plants Bacopa monniera, Emblica officinalis, Glycyrrhiza glabra, Mangifera indica and Syzygium aromaticum was studied for its antioxidant activity. The protective effect of DHC-1 in isoproterenol-induced myocardial infarction and cisplatin-induced renal damage were studied. A significant reduction in the serum markers of heart and kidney damage and the extent of lipid peroxidation with a concomitant increase in the enzymatic (SOD and CAT) and non-enzymatic antioxidants (reduced glutathione) were observed in DHC-1 pretreated animals compared with the isoproterenol or cisplatin alone treated animals. Thus it can be concluded that DHC-1 possesses a protective effect against both damaged heart and kidneys in rats. This beneficial effect may be attributed, at least in part, to its antioxidant activity.

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