Format

Send to

Choose Destination
Clin Exp Immunol. 2005 Jun;140(3):395-407.

Mammalian Toll-like receptors: to immunity and beyond.

Author information

1
Gram-Positive Molecular Pathogenesis Group, Department of Infectious Diseases, Division of Investigative Science, Faculty of Medicine, Imperial College, London, UK. p.hopkins@imperial.ac.uk

Abstract

Toll-like receptors (TLRs) constitute an archetypal pattern recognition system. Their sophisticated biology underpins the ability of innate immunity to discriminate between highly diverse microbial pathogens and self. However, the remarkable progress made in describing this biology has also revealed new immunological systems and processes previously hidden to investigators. In particular, TLRs appear to have a fundamental role in the generation of clonal adaptive immune responses, non-infectious disease pathogenesis and even in the maintenance of normal mammalian homeostasis. Although an understanding of TLRs has answered some fundamental questions at the host-pathogen interface, further issues, particularly regarding therapeutic modulation of these receptors, have yet to be resolved.

PMID:
15932500
PMCID:
PMC1809390
DOI:
10.1111/j.1365-2249.2005.02801.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center