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J Org Chem. 2005 Jun 10;70(12):4784-96.

A simple and efficient copper-catalyzed procedure for the hydrosilylation of hindered and functionalized ketones.

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  • 1Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA.

Abstract

The catalytic hydrosilylation of highly hindered and functionalized ketones is described. The combination of inexpensive catalyst precursors, CuCl and NHC.HX (NHC = N-heterocyclic carbene), leads to a highly efficient reduction mediator for the preparation of silyl ethers from unfunctionalized and functionalized alkyl, cyclic, bicyclic, aromatic, and heteroaromatic ketones. A series of catalyst precursors have been structurally characterized and a catalyst-structure activity relationship is discussed.

PMID:
15932319
DOI:
10.1021/jo050397v
[PubMed]
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