Format

Send to

Choose Destination
J Clin Invest. 2005 Jun;115(6):1461-3.

Lessons learned from cancer may help in the treatment of pulmonary hypertension.

Author information

1
INSERM U651 and Département de Physiologie, Hôpital H. Mondor, Assistance Publique des Hôpitaux de Paris, Créteil, France. serge.adnot@hmn.ap-hop-paris.fr

Abstract

Hyperplasia of pulmonary artery SMCs (PASMCs) is a pathological hallmark of pulmonary arterial hypertension (PAH). In this issue of the JCI, McMurtry et al. report that adenovirus-mediated overexpression of survivin--a multipotent inhibitor of apoptosis--induces PAH in rats, whereas inhalation of an adenovirus vector encoding a mutant survivin gene with dominant-negative properties reverses established monocrotaline-induced PAH. These findings raise important issues regarding the role of survivin in the pathogenesis of PAH, its value as a prognostic indicator, and its use as a target for new therapeutic strategies.

PMID:
15931382
PMCID:
PMC1137011
DOI:
10.1172/JCI25399
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Society for Clinical Investigation Icon for PubMed Central
Loading ...
Support Center