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J Clin Invest. 2005 Jun;115(6):1440-8.

Finding schizophrenia genes.

Author information

1
Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom.

Abstract

Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.

PMID:
15931379
PMCID:
PMC1137005
DOI:
10.1172/JCI24759
[Indexed for MEDLINE]
Free PMC Article

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