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J Epidemiol. 2005 May;15(3):70-7.

Body mass index and mortality in a middle-aged Japanese cohort.

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1
Department of Virology and Preventive Medicine, Gunma University School of Medicine, Japan. r-hayashi@mrh.biglobe.ne.jp

Abstract

BACKGROUND:

The relative risk of mortality in low and high body mass index (BMI) categories in various ethnic groups remains a controversial subject.

METHODS:

To examine the relationship between BMI and mortality, a population-based prospective cohort study was conducted in two areas of Gunma Prefecture, Japan, in 1993. A total of 5,554 men and 5,827 women aged 40-69 years completed a self-administered questionnaire and were followed up until the year 2000. The hazard ratios (HRs) were estimated by the Cox proportional hazards model for different BMI classes.

RESULTS:

During the seven year follow-up period, 329 men and 147 women died. As compared with those in the reference BMI category (22.0-24.9 kg/m(2)), men and women in the lowest BMI category (<18.5 kg/m(2)) had a HR (95% confidence interval [CI]) of death from all-causes of 2.66 (1.59-4.46) and 3.14 (1.38-7.13), respectively, and women in the highest BMI category (28.0+ kg/m(2)) had a HR of death of 3.25 (1.48-7.15), after adjusting for all possible confounding factors including smoking and after excluding deaths occurring during the first three years of follow-up.

CONCLUSION:

In this prospective study of a Japanese cohort consisting of subjects ranging in age from 40 to 69 years, the curve depicting the relationship between BMI and all-cause mortality was L-shaped in men and U-shaped in women.

PMID:
15930802
[Indexed for MEDLINE]
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