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Anal Bioanal Chem. 2005 Jun;382(4):918-25. Epub 2005 Jun 1.

Fiber-optic nanosensors for single-cell monitoring.

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Oak Ridge National Laboratory, Advanced Biomedical Science and Technology Group, Oak Ridge, TN 37831-6101, USA.


This article is an overview of the fabrication, operating principles, and applications of fiber-optic nanobiosensors with the capability of in-vivo analysis at the single-cell level. Recently, the cross-disciplinary integration of nanotechnology, biology, and photonics has been revolutionizing important areas in molecular biology, especially diagnostics and therapy at the molecular and cellular level. Fiber-optic nanobiosensors are a unique class of biosensor that enable analytical measurements in individual living cells and the probing of individual chemical species in specific locations within a cell. This article provides a review of the research performed in our laboratory and discusses the usefulness and potential of this nanotechnology-based biosensor system in biological research and its applications to biomonitoring of individual cells.

[Indexed for MEDLINE]

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