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Nat Rev Mol Cell Biol. 2005 Jun;6(6):499-505.

An emergency response team for membrane repair.

Author information

1
Department of Anatomy and Cellular Biology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30921, USA. pmcneil@mail.mcg.edu
2
Med Coll GA, Augusta

Abstract

On demand, rapid Ca(2+)-triggered homotypic and exocytic membrane-fusion events are required to repair a torn plasma membrane, and we propose that this emergency-based fusion differs fundamentally from other rapid, triggered fusion reactions. Emergency fusion might use a specialized protein and organelle emergency response team that can simultaneously promote impromptu homotypic fusion events between organelles and exocytic fusion events along the vertices between these fusion products and the plasma membrane.

PMID:
15928713
DOI:
10.1038/nrm1665
[Indexed for MEDLINE]

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