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Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8351-6. Epub 2005 May 31.

Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex.

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1
Department of Neurosurgery and Neurology, University of Iowa College of Medicine, Iowa City, IA 52242, USA.

Abstract

Lesion and functional imaging studies have shown that the ventromedial prefrontal cortex is critically involved in the avoidance of risky choices. However, detailed descriptions of the mechanisms that underlie the establishment of such behaviors remain elusive, due in part to the spatial and temporal limitations of available research techniques. We investigated this issue by recording directly from prefrontal depth electrodes in a rare neurosurgical patient while he performed the Iowa Gambling Task, and we concurrently measured behavioral, autonomic, and electrophysiological responses. We found a robust alpha-band component of event-related potentials that reflected the mismatch between expected outcomes and actual outcomes in the task, correlating closely with the reward-related error obtained from a reinforcement learning model of the patient's choice behavior. The finding implicates this brain region in the acquisition of choice bias by means of a continuous updating of expectations about reward and punishment.

PMID:
15928095
PMCID:
PMC1149421
DOI:
10.1073/pnas.0500899102
[Indexed for MEDLINE]
Free PMC Article
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