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Microbes Infect. 2005 Jun;7(7-8):1040-8.

CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-Ig.

Author information

1
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.

Abstract

The synthetic immunomodulator cytotoxic T lymphocyte antigen 4-Ig (CTLA-4-Ig) initiates effects in human monocyte-derived dendritic cells (DC) that rely on immunosuppressive tryptophan catabolism. However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4.

PMID:
15925532
DOI:
10.1016/j.micinf.2005.03.030
[Indexed for MEDLINE]

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