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Eur J Pharmacol. 2005 Jun 1;516(2):180-1.

Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis.

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  • 1Department of Medicinal Pharmacology, Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan. a.takaoka@po.rd.taisho.co.jp

Abstract

To search for the pruritogen of atopic dermatitis, a characteristic symptom in atopic dermatitis patients, we examined interleukin-31 (IL-31) mRNA expression in NC/Nga mice as an animal model of atopic dermatitis. The expression of IL-31 mRNA in the skin of NC/Nga mice with scratching behavior was significantly higher than that in NC/Nga mice without scratching behavior. Our findings suggest that IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis.

PMID:
15925362
DOI:
10.1016/j.ejphar.2005.04.040
[PubMed - indexed for MEDLINE]
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