Objective: To compare the effect of HMG and rhFSH on oocyte quality in ICSI cycle.
Setting: Vali-e-Asr university teaching hospital.
Method: Prospective single-blind randomized clinical trial.
Subjects: Sixty women undergoing ovarian stimulation for ICSI were randomized to receive a standard protocol of either HMG or rhFSH in down-regulation cycles.
Interventions: Prior to microinjection, each oocyte was assessed regarding the nuclear maturity, morphology of zona plucida, cytoplasmic appearance and polar body morphology. Fertilization rate was followed.
Main outcome: The percentage of metaphase II oocytes in HMG and rhFSH groups.
Statistical analysis: Statistical analyses were carried out by the Mann-Whitney, Fisher's exact, chi2 tests and Student's t-test.
Results: No significant differences were found between two groups in regard to the demographic data, the ovarian response and pregnancy/implantation rates (P>0.05). The percentage of metaphase II oocytes in HMG and rhFSH groups were 81.3% versus 80.6%, respectively.
Conclusions: There were no significant differences between parameters such as, oocyte quality and percentage of metaphase II oocytes between these two groups.