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Neuron. 2005 Jun 2;46(5):703-13.

The hippocampal-VTA loop: controlling the entry of information into long-term memory.

Author information

1
Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA. lisman@brandeis.edu

Abstract

In this article we develop the concept that the hippocampus and the midbrain dopaminergic neurons of the ventral tegmental area (VTA) form a functional loop. Activation of the loop begins when the hippocampus detects newly arrived information that is not already stored in its long-term memory. The resulting novelty signal is conveyed through the subiculum, accumbens, and ventral pallidum to the VTA where it contributes (along with salience and goal information) to the novelty-dependent firing of these cells. In the upward arm of the loop, dopamine (DA) is released within the hippocampus; this produces an enhancement of LTP and learning. These findings support a model whereby the hippocampal-VTA loop regulates the entry of information into long-term memory.

PMID:
15924857
DOI:
10.1016/j.neuron.2005.05.002
[Indexed for MEDLINE]
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