Format

Send to

Choose Destination
See comment in PubMed Commons below
Cancer Lett. 2005 Jul 8;225(1):35-40. Epub 2004 Dec 24.

Growth of LNCaP cells in monoculture and coculture with osteoblasts and response to tNOX inhibitors.

Author information

1
Department of Foods and Nutrition, Purdue University, 700 W. State Street, West Lafayette, IN 47907-205, USA.

Abstract

An in vitro coculture model of prostate cancer cells (LNCaP) with human osteoblasts (hFOB) was utilized to define the efficacy of the tNOX inhibitors EGCg, capsaicin, Capsibiol-T and phenoxodiol against bone metastasis of prostate cancer alone and in combination with Taxol and cisplatin. In general, the LNCaP cells were more resistant to treatment with EGCg, capsaicin, phenoxodiol and Taxol when grown in coculture than when grown in monoculture. Only with Capsibiol-T (50 microM) was growth of LNCaP cells in coculture inhibited comparable with monoculture. Pretreatment with Capsibiol-T followed by the treatment with Taxol had an additive effect on reduction of viability of LNCaP cells in monoculture. In contrast, an antagonistic effect of cisplatin was observed following capsaicin pretreatment.

PMID:
15922855
DOI:
10.1016/j.canlet.2004.11.017
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center