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Trends Genet. 2005 Jun;21(6):322-6.

Mammalian microRNAs derived from genomic repeats.

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University of Illinois at Chicago, UIC Psychiatric Institute, MC 912, 1601 W. Taylor Street, Chicago, IL 60612, USA.


In this article, we show that a subset of conventional mammalian microRNAs is derived from LINE-2 transposable elements and other genome repeats. These repeat-derived microRNAs arise from conventional precursor hairpins and are distinct from the rasiRNAs, which appear to be processed from long double-stranded RNA precursors. The insertion of transposable elements into new genomic sites appears to be one of the driving-forces that create new microRNAs during mammalian evolution. Two of the LINE-2-derived microRNAs exhibit perfect complementarity to a large family of mRNA and EST transcripts that contain portions of MIR and other LINE-2 elements in their 3'-untranslated regions.

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