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Trends Genet. 2005 Jun;21(6):318-22.

Haplotype-based genetics in mice and rats.

Author information

1
Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. ecuppen@niob.nkaw.nl

Abstract

Haplotype blocks are conceptually defined as genomic segments harbouring sets of coupled polymorphisms that reflect a common ancestral origin. Experimentally, however, haplotype blocks are characterized using computational algorithms based on incomplete inventories of polymorphisms. Haplotype blocks and their deduced strain-distribution patterns are considered to be extremely powerful for use in genetic association and mapping experiments in laboratory mice and rats. However, recent high-density SNP screening in commonly used mouse inbred strains reveals a complex pattern, suggesting that the current expectations for the use of haplotype blocks in genetic mapping will have to be revisited.

PMID:
15922828
DOI:
10.1016/j.tig.2005.03.010
[Indexed for MEDLINE]

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