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Toxicon. 2005 Jun 15;45(8):1115-32. Epub 2005 Apr 19.

Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved.

Author information

1
Laboratório Especial de Toxinologia Aplicada-CAT-CEPID, Instituto Butantan, Av. Vital Brasil 1500, 05503-900 São Paulo-SP, Brazil. solangeserrano@butantangov.br

Abstract

Snake venom glands synthesize a variety of serine proteinases capable of affecting the haemostatic system. They act on macromolecular substrates of the coagulation, fibrinolytic, and kallikrein-kinin systems, and on platelets to cause an imbalance of the haemostatic system of the prey. In this review we describe their biochemical/biophysical characteristics, biological activities as well as aspects of their evolution and structure-activity relationship.

PMID:
15922778
DOI:
10.1016/j.toxicon.2005.02.020
[Indexed for MEDLINE]

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