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Trends Immunol. 2005 Jul;26(7):352-4.

Dectin-1 escape by fungal dimorphism.

Author information

1
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK OX1 3RE.

Abstract

Candida albicans, a medically important fungus, exists primarily as yeast and filamentous forms. Its cell wall is rich in beta-glucans, which are recognized by a lectin-like innate immune receptor, Dectin-1. A recent study shows that exposure of glucan, by yeasts but not filaments, determines Dectin-1-dependent uptake by macrophages, and thus represents a novel immune evasion mechanism. Here, we discuss the insights these results provide in relation to macrophage interactions with C. albicans and pathogen entry.

PMID:
15922664
DOI:
10.1016/j.it.2005.05.005
[Indexed for MEDLINE]

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