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Curr Opin Neurobiol. 2005 Jun;15(3):370-8.

Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate.

Author information

1
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195, USA.

Abstract

Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work has characterized the regulation of a wide range of ion channels by phosphatidylinositol 4,5-bisphosphate, helping to redefine the role of this lipid in cells and in neurobiology. In most cases, phosphatidylinositol 4,5-bisphosphate increases channel activity, and its hydrolysis by phospholipase C reduces channel activity.

PMID:
15922587
DOI:
10.1016/j.conb.2005.05.005
[Indexed for MEDLINE]

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