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Int J Gynaecol Obstet. 2005 Jul;90(1):39-43.

Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome.

Author information

1
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, No.92, Section 2, Chung-Shan North Road, Taipei, Taiwan. hu4416@yahoo.com

Abstract

OBJECTIVE:

To evaluate the effect of ultra-short (12 days) metformin pretreatment in clomiphene-citrate (CC) resistant polycystic ovary syndrome (PCOS).

METHOD:

Eighty women with CC-resistant PCOS were randomly allocated to metformin pretreatment or usual treatment. Forty women received 1500 mg metformin daily for 12 days, followed by clomiphene 150 mg daily for 5 days along with metformin. Forty women (control group) received the same dose of clomiphene but no metformin pretreatment.

RESULTS:

In the metformin group, 17 (42.5%) women ovulated, and 6 (15%) conceived. In the control group, 5 (12.5%) women ovulated but none conceived. Compared with the control group, the metformin group had significantly higher ovulation (P = 0.03) and pregnancy rates (P = 0.026).

CONCLUSION:

Twelve days of metformin pretreatment improves ovulation and pregnancy rates in women with CC-resistant PCOS.

PMID:
15921686
DOI:
10.1016/j.ijgo.2005.04.004
[Indexed for MEDLINE]
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