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Exp Gerontol. 2005 May;40(5):363-8. Epub 2005 Mar 29.

New developments in telomere length analysis.

Author information

  • 1Department of Pathology, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. bairddm@cardiff.ac.uk

Abstract

Telomeres provide an essential 'capping' function, which prevents the natural end of a chromosome from being recognised as a simple dsDNA break. The biology of human telomeres is inextricably linked with both cancer and ageing. As such there is considerable interest in determining the length of these essential and dynamic structures. Here I review, from the standpoint of ageing research in humans, the current situation with regards to technologies available to determine telomere length in human cells and tissues.

PMID:
15919587
DOI:
10.1016/j.exger.2005.02.008
[PubMed - indexed for MEDLINE]
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