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Arch Pharm Res. 2005 Apr;28(4):391-4.

Synthesis of 3-alkylthio-6-allylthiopyridazine derivatives and their antihepatocarcinoma activity.

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1
College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea. skkwon@duksung.ac.kr

Erratum in

  • Arch Pharm Res. 2005 Jul;28(7):875.

Abstract

The allylthio group of allicin and other organosulfur compounds, isolated from garlic, is considered a pharmacophore, and a key structure component of the molecule, which affords biological activities. In the foregoing studies, various 3-alkoxy-6-allylthiopyridazine derivatives (K-compounds) were synthesized, and their biological activities tested in animals. As expected, the various derivatives showed good hepatoprotective activities on carbon tetrachloride-treated mice and aflatoxin B1-treated rats, and chemopreventive activities on hepatocarcinoma cells in rats. Other new pyridazine derivatives, with the oxygen atom at the 3-position of the 3-alkoxy-6-allylthiopyridazine displaced by sulfur (S), were synthesized, and their activities tested in vitro. Thio-K6, one of the sulfur-substituted compounds, showed better chemopreventive activity toward hepatocarcinoma cells.

PMID:
15918510
DOI:
10.1007/bf02977666
[Indexed for MEDLINE]

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