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Org Biomol Chem. 2005 Jun 7;3(11):2122-5. Epub 2005 Apr 28.

Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug.

Author information

1
National Creative Research Initiative Center for Smart Supramolecules, Division of Molecular and Life Sciences, Pohang University of Science and Technology San 31 Hyojadong, Pohang 790-784, Republic of Korea.

Abstract

Oxaliplatin forms a stable 1:1 inclusion complex with cucurbit[7]uril as indicated by NMR, mass spectrometry, isothermal titration calorimetry and X-ray crystallography. The encapsulation of the drug results in a large enhancement in stability, a moderate decrease in reactivity toward guanosine but a much larger decrease in reactivity toward L-methionine, which suggests the encapsulation not only increases the stability of the drug but also may reduce unwanted side effects caused by protein binding of the platinum drug. A preliminary in vitro assay using various tumor cell lines reveals that the encapsulation results in a decrease in the antitumor activity of oxaliplatin.

PMID:
15917899
DOI:
10.1039/b504487a
[Indexed for MEDLINE]

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