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Int J Obes (Lond). 2005 Jul;29(7):872-4.

Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity.

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1
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Abstract

OBJECTIVE:

To investigate whether genetic variation in the cyclic GMP-dependent protein kinase gene (PRKG1) is associated with obesity.

METHODS:

The study included 143 individuals from New York City area, NY, USA. The subjects were sampled on the basis of body mass index (BMI): obese (BMI ranging from 33.8 to 89.5 kg/m(2)), and nonobese (BMI ranging from 16.0 to 29.4 kg/m(2)). The association between C2276T polymorphism in PRKG1 gene and obesity was tested using linear regression analysis.

RESULTS:

BMI levels were predicted by linear regression models adjusted for demographic factors. An analysis was performed twice: in individuals of all ethnic backgrounds and in European-Americans only. In both cases, genotype did not have a significant effect.

CONCLUSION:

We found no evidence that the C2276T polymorphism in the PKRG1 gene is associated with obesity.

PMID:
15917860
DOI:
10.1038/sj.ijo.0802973
[Indexed for MEDLINE]
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