Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Obes (Lond). 2005 Sep;29(9):1130-6.

Ghrelin increases food intake in obese as well as lean subjects.

Author information

  • 1Department of Metabolic Medicine, Imperial College, London, Hammersmith Hospital Campus, London, UK.

Abstract

OBJECTIVE:

To investigate whether effects on food intake are seen in obese subjects receiving exogenous administration of ghrelin.

DESIGN:

Randomised, double-blind, placebo-controlled study of intravenous ghrelin at doses 1 pmol/kg/min and 5 pmol/kg/min.

SUBJECTS:

In all, 12 healthy lean subjects (mean body mass index (BMI) 20.5+/-0.17 kg/m(2)) and 12 healthy overweight and obese subjects (mean BMI 31.9+/-1.02 kg/m(2)).

MEASUREMENTS:

Food intake, appetite and palatability of food, ghrelin and other obesity-related hormones, growth hormone.

RESULTS:

Low-dose infusion of ghrelin increased ad libitum energy intake at a buffet meal in the obese group only (mean increase 36.6+/-9.4%, P<0.01.) High-dose ghrelin infusion increased energy intake in both groups (mean increase 20.1+/-10.6% in the lean and 70.1+/-15.5% in the obese, P<0.01 in both cases.) Ghrelin infusion increased palatability of food in the obese group.

CONCLUSION:

Ghrelin increases food intake in obese as well as lean subjects. Obese people are sensitive to the appetite-stimulating effects of ghrelin and inhibition of circulating ghrelin may be a useful therapeutic target in the treatment of obesity.

PMID:
15917842
DOI:
10.1038/sj.ijo.0803001
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center