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Antimicrob Agents Chemother. 2005 Jun;49(6):2504-6.

Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid.

Author information

1
Pediatric Pharmacology Research Unit (PPRU), University of California, San Diego, 200 West Arbor Drive, MC 8214, San Diego, CA 92103-8214, USA. ecapparelli@ucsd.edu

Abstract

The distribution of abacavir into the cerebrospinal fluid (CSF) was assessed by use of a population pharmacokinetic analysis. Plasma and CSF abacavir concentrations in 54 subjects were determined. The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication.

PMID:
15917556
PMCID:
PMC1140502
DOI:
10.1128/AAC.49.6.2504-2506.2005
[Indexed for MEDLINE]
Free PMC Article

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