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Semin Fetal Neonatal Med. 2005 Aug;10(4):341-50.

Metabolic adaptation at birth.

Author information

1
Newcastle Neonatal Services, Royal Victoria Infirmary, Department of Child Health, Queen Victoria Road, Newcastle upon Tyne NE1 4 LP, UK. m.p.ward-platt@ncl.ac.uk

Abstract

After birth, the neonate must make a transition from the assured continuous transplacental supply of glucose to a variable fat-based fuel economy. The normal infant born at term accomplishes this transition through a series of well-coordinated metabolic and hormonal adaptive changes. The patterns of adaptation in the preterm infant and the baby born after intrauterine growth restriction are, however, different to that of a full-term neonate, with the risk for former groups that there will be impaired counter-regulatory ketogenesis. There is much less precise linkage of neonatal insulin secretion to prevailing blood glucose concentrations. These patterns of metabolic adaptation are further influenced by feeding practices.

PMID:
15916931
DOI:
10.1016/j.siny.2005.04.001
[Indexed for MEDLINE]

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