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Eur J Obstet Gynecol Reprod Biol. 2005 Nov 1;123(1):62-6.

Light-induced fluorescence of the human cervix decreases after prostaglandin application for induction of labor at term.

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1
Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX 77555-1062, USA.

Abstract

OBJECTIVE:

To define the changes in cervical light-induced fluorescence (LIF), an index of cross-linked collagen, after the use of locally applied prostaglandin preparations for labor induction at term and the correlation between LIF and Bishop-Score.

STUDY DESIGN:

The characteristic LIF of cervical collagen was measured from the surface of the cervix using a specially designed instrument (collascope) in 41 gravidas undergoing labor induction at term by prostaglandins. LIF and Bishop-Score were obtained directly before and 4h after the administration of prostaglandin. Paired Student's t-test, Wilcoxon Signed Rank test, Linear Regression, Spearman correlation and Fisher Exact test were used as appropriate.

RESULTS:

Cervical LIF decreased significantly after prostaglandin application (0.982+/-0.04 [before] to 0.885+/-0.037 [after], p=0.025). The decrease in LIF correlated with the initial LIF before PG-application (r=0.61). The Bishop-Score increased in all 41 patients. No correlation was found between LIF versus Bishop-Score.

CONCLUSIONS:

Cervical application of prostaglandins decreases the amount of cross-linked collagen as measured by LIF. This effect was observed only in patients with a prior high cross-linked collagen.

PMID:
15916844
DOI:
10.1016/j.ejogrb.2005.03.006
[Indexed for MEDLINE]
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