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Exp Eye Res. 2005 Aug;81(2):123-37.

Retinal remodeling during retinal degeneration.

Author information

1
Moran Eye Center, 75 North Medical Drive, Rm 3339A, Salt Lake City, UT 84132, USA. bryan.jones@m.cc.utah.edu

Abstract

Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina. As in other central nervous system degenerations, deafferentation activates remodeling. Neuronal remodeling is the common fate of all photoreceptor degenerations.

PMID:
15916760
DOI:
10.1016/j.exer.2005.03.006
[Indexed for MEDLINE]

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