Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Drug Discov. 2005 Jun;4(6):461-7.

Can cell systems biology rescue drug discovery?

Author information

1
Department of Pathology, Stanford University, Stanford, California 94305-5324, USA. ebutcher@stanford.edu

Abstract

The focus of innovation in current drug discovery is on new targets, yet compound efficacy and safety in biological models of disease - not target selection - are the criteria that determine which drug candidates enter the clinic. We consider a biology-driven approach to drug discovery that involves screening compounds by automated response profiling in disease models based on complex human-cell systems. Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development.

Republished in

PMID:
15915152
DOI:
10.1038/nrd1754
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center