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J Gen Virol. 2005 Jun;86(Pt 6):1753-7.

Wild-type Rinderpest virus uses SLAM (CD150) as its receptor.

Author information

1
Institute for Animal Health, Ash Road, Pirbright, Surrey GU24 0NF, UK. michael.baron@bbsrc.ac.uk

Abstract

Rinderpest virus (RPV) is a morbillivirus, related closely to the human pathogen Measles virus (MV). Although cell culture-adapted strains of RPV can infect many kinds of cell from different hosts, one such strain has previously been shown to have a detectable preference for cells expressing the MV receptor CD150 (SLAM), a protein found only on certain types of activated T cells, B cells and dendritic cells. Here, it is shown that the wild-type, virulent parent of the most common vaccine strain of RPV requires CD150 as a receptor, whilst the cell culture-adapted vaccine strain has acquired the ability to use heparan sulphate as an alternative receptor.

PMID:
15914854
DOI:
10.1099/vir.0.80836-0
[Indexed for MEDLINE]
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