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FEBS Lett. 2005 Jun 13;579(15):3336-41. Epub 2005 Apr 26.

Spatial coordination of CD8 and TCR molecules controls antigen recognition by CD8+ T-cells.

Author information

1
Department of Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel. israel.pecht@weizmann.ac.il

Abstract

The interactions between the TCR and peptides bound to class I MHC encoded molecules (pMHC) and a mechanism for CD8 cooperation in this process are reviewed. Observation of two TCR/CD8 populations with different lateral diffusion rate constants as well as two distinct association phases of class I MHC tetramers ((pMHC)4) with T-cells suggest that the most efficient pMHC-T-cell association route corresponds to a fast tetramer binding to a colocalized CD8/TCR population, which apparently resides within membrane rafts. Thus, ligand-cell association starts by pMHC binding to the CD8. This rather fast step promotes pMHC association with CD8-proximal TCRs and thereby enhances the overall association process. The model suggests that this raft-associated CD8-TCR subpopulation is responsible for evoking T-cell activation.

PMID:
15913613
DOI:
10.1016/j.febslet.2005.04.025
[Indexed for MEDLINE]
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