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Bioorg Med Chem Lett. 2005 Jun 2;15(11):2758-60.

Synthesis and biological studies of yohimbine derivatives on human alpha2C-adrenergic receptors.

Author information

1
Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center, Memphis, 38163, USA.

Abstract

A series of yohimbine derivatives was synthesized and evaluated for binding affinity at the human alpha(2C)-adrenergic receptors expressed in Chinese hamster ovary cells. It has been found that compound 5 shows a higher affinity for alpha(2C)-AR than the parent compound yohimbine 1, thereby illustrating that the nature of the linkers affect binding potencies on these receptors.

PMID:
15911252
DOI:
10.1016/j.bmcl.2005.03.116
[Indexed for MEDLINE]

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