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Bioorg Med Chem Lett. 2005 Jun 2;15(11):2734-7.

Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase.

Author information

1
Department of Medicinal Chemistry, Aventis Pharmaceuticals, Bridgewater, NJ 08807, USA. corey.hopkins@aventis.com

Abstract

A new series of novel mast cell tryptase inhibitors is reported, which features the use of an indole structure as the hydrophobic substituent on a m-benzylaminepiperidine template. The best members of this series display good in vitro activity and excellent selectivity against other serine proteases.

PMID:
15911249
DOI:
10.1016/j.bmcl.2005.04.002
[Indexed for MEDLINE]

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